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Article

A polymorphism of LOC387715 gene is associated with age-related macular degeneration in the Japanese population.

Neuroscience letters - 27 Feb 2007

Tanimoto Seiji, Tamura Hiroki, Ue Takahiro, Yamane Ken, Maruyama Hirofumi, Kawakami Hideshi, Kiuchi Yoshiaki

Abstract excerpt

Age-related macular degeneration (AMD) is one of the leading causes of blindness among older adults in developed countries and also in Japan. Previous research suggests that AMD is etiologically a complex disease, caused by multiple genes and environmental factors. Association studies have identified that a complement factor H gene (CFH) variant is a major risk factor for AMD in Caucasians. However, we and two...

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Source

Identifiers

PMID: 17194541
DOI: 10.1016/j.neulet.2006.12.011

Genes

CFH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A polymorphism of LOC387715 gene is associated with age-related macular degeneration in the Japanese population.PMID 17194541Read ↗

Neovascular age-related macular degeneration and its association with LOC387715 and complement factor H polymorphism.Semantic proximity Read ↗

Age-related macular degeneration and association of CFH Y402H and LOC387715 A69S polymorphisms in a Turkish population.Semantic proximity Read ↗

LOC387715/HTRA1 polymorphisms, smoking and combined effects on exudative age-related macular degeneration in a Korean population.Semantic proximity Read ↗

The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples.Semantic proximity Read ↗

Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population.Semantic proximity Read ↗

Complement factor H and LOC387715 gene polymorphisms in a Greek population with age-related macular degeneration.Semantic proximity Read ↗

Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk.Semantic proximity Read ↗

Correlation of complement factor H gene polymorphisms with exudative age-related macular degeneration in a Chinese cohort.Semantic proximity Read ↗

Association between complement factor H gene polymorphisms and neovascular age-related macular degeneration in Koreans.Semantic proximity Read ↗

The LOC387715 gene, smoking, body mass index, environmental associations with advanced age-related macular degeneration.Semantic proximity Read ↗

Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.Semantic proximity Read ↗

Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration.Semantic proximity Read ↗

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