[Histology and molecular biology of GIST].

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Article

[Histology and molecular biology of GIST].

Bulletin de l'Academie nationale de medecine - 1 Jan 2000

Emile Jean-François

Abstract excerpt

Gastrointestinal stromal tumors (GIST) are the most frequent sarcomas but were underdiagnosed until the beginning of this century. GIST derive from interstitial cells of Cajal and may develop all along the digestive tract. GIST are characterized by the expression of KIT (CD117), and also DOG-1, which was recently discovered by transcriptome analysis. Gain-of-function mutations of the tyrosine kinase receptors KIT...

Topics

Anoctamin-1
Chloride Channels
Gastrointestinal Neoplasms
Gastrointestinal Stromal Tumors
Genetic Predisposition to Disease
Humans
Mutation
Neoplasm Proteins
Proto-Oncogene Proteins c-kit
Receptor, Platelet-Derived Growth Factor alpha

Source

Open in PubMed

Identifiers

PMID: 23550446

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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