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Article

Genetic control of alternative splicing in the TAP2 gene: possible implication in the genetics of type 1 diabetes.

Diabetes - 1 Jan 2007

Qu Hui-Qi, Lu Yang, Marchand Luc, Bacot François, Fréchette Rosalie, Tessier Marie-Catherine, Montpetit Alexandre, Polychronakos Constantin

Abstract excerpt

The transporter 2, ATP-binding cassette, subfamily B (TAP2) is involved in the transport of antigenic peptides to HLA molecules. Coding TAP2 polymorphisms shows a strong association with type 1 diabetes, but it is not clear whether this association may be entirely due to linkage disequilibrium with HLA DR and DQ. Functionally, rat Tap2 nonsynonymous single-nucleotide polymorphisms (nsSNPs) confer differential...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 2

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Source

Identifiers

PMID: 17192492
DOI: 10.2337/db06-0865

Genes

TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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