Article
[Somatic mutations of mitochondrial DNA in thyroid papillary carcinoma].
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery - 1 Oct 2006
Sun Tuan-qi, Wu Yi, Ji Qing-hai, Bian Jian-chao, Wang Zhuo-ying
Abstract excerpt
OBJECTIVE: To analyze the somatic mutations in the D-loop of mtDNA and further evaluate the possibility of mitochondrial genetic instability in thyroid papillary carcinoma. METHODS: Hypervariable regions ( HVR-I and HVR-II) in the D-loop of mtDNA from the specimen of 35 thyroid papillary cancers and matched lymphocytes were amplified by PCR, and then were sequenced. RESULTS: Comparing the sequences of tumors to...
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