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Article

The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis.

Journal of lipid research - 1 Feb 2017

Ferguson Daniel, Zhang Jun, Davis Matthew A, Helsley Robert N, Vedin Lise-Lotte, Lee Richard G, Crooke Rosanne M, Graham Mark J, Allende Daniela S, Parini Paolo, Brown J Mark

Abstract excerpt

Hepatitis C virus (HCV) is an enveloped RNA virus responsible for 170 million cases of viral hepatitis worldwide. Over 50% of chronically infected HCV patients develop hepatic steatosis, and steatosis can be induced by expression of HCV core protein (core) alone. Additionally, core must associate with cytoplasmic lipid droplets (LDs) for steatosis development and viral particle assembly. Due to the importance of...

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Source

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Identifiers

PMID: 27941027
DOI: 10.1194/jlr.M073734
PMCID: PMC5282958

Genes

PLIN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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