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Article

Basis of lethality in C. elegans lacking CUP-5, the Mucolipidosis Type IV orthologue.

Developmental biology - 15 May 2006

Schaheen Lara, Dang Hope, Fares Hanna

Abstract excerpt

Mutations in MCOLN1, which encodes the protein h-mucolipin-1, result in the lysosomal storage disease Mucolipidosis Type IV. Studies on CUP-5, the human orthologue of h-mucolipin-1 in Caenorhabditis elegans, have shown that these proteins are required for lysosome biogenesis. We show here that the lethality in cup-5 mutant worms is due to two defects, starvation of embryonic cells and general developmental...

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Source

Identifiers

PMID: 16530747
DOI: 10.1016/j.ydbio.2006.02.008

Genes

MCOLN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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