Article
BTG1 mutation yields supercompetitive B cells primed for malignant transformation.
Science (New York, N.Y.) - 20 Jan 2023
Mlynarczyk Coraline, Teater Matt, Pae Juhee, Chin Christopher R, Wang Ling, Arulraj Theinmozhi, Barisic Darko, Papin Antonin, Hoehn Kenneth B, Kots Ekaterina, Ersching Jonatan, Bandyopadhyay Arnab, Barin Ersilia, Poh Hui Xian, Evans Chiara M, Chadburn Amy, Chen Zhengming, Shen Hao, Isles Hannah M, Pelzer Benedikt, Tsialta Ioanna, Doane Ashley S, Geng Huimin, Rehman Muhammad Hassan, Melnick Jonah, Morgan Wyatt, Nguyen Diu T T, Elemento Olivier, Kharas Michael G, Jaffrey Samie R, Scott David W, Khelashvili George, Meyer-Hermann Michael, Victora Gabriel D, Melnick Ari
Abstract excerpt
Multicellular life requires altruistic cooperation between cells. The adaptive immune system is a notable exception, wherein germinal center B cells compete vigorously for limiting positive selection signals. Studying primary human lymphomas and developing new mouse models, we found that mutations affecting BTG1 disrupt a critical immune gatekeeper mechanism that strictly limits B cell fitness during antibody...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.