Article
Reconstituted expression of menin in Men1-deficient mouse Leydig tumour cells induces cell cycle arrest and apoptosis.
European journal of cancer (Oxford, England : 1990) - 1 Jan 2007
Hussein Nader, Casse Huguette, Fontanière Sandra, Morera Anne-Marie, Asensio Marie J, Bakeli Skander, Lu Jie L, Coste Isabelle, Di Clemente Nathalie, Bertolino Philippe, Zhang Chang X
Abstract excerpt
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary syndrome caused by the inactivation of the responsible gene, MEN1. To date, the lack of MEN1-deficient cell lines derived directly from MEN1 tumours has hampered the detailed study of the MEN1 gene. We have established several stable Men1-deficient Leydig cell tumour (LCT) lines derived from a Leydig cell tumour developed in a male heterozygous Men1...
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