Twenty years of menin: emerging opportunities for restoration of transcriptional regulation in MEN1

Abstract excerpt

Since the discovery of the multiple endocrine neoplasia type 1 ( MEN1 ) gene in 1997, elucidation of the molecular function of its protein product, menin, has been a challenge. Biochemical, proteomics, genetics and genomics approaches have identified various potential roles, which converge on gene expression regulation. The most consistent findings show that menin connects transcription factors and...

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