Article
Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover.
Cancer research communications - 1 Jul 2023
Duan Suzann, Sheriff Sulaiman, Elvis-Offiah Uloma B, Witten Brandon L, Sawyer Travis W, Sundaresan Sinju, Cierpicki Tomasz, Grembecka Jolanta, Merchant Juanita L
Abstract excerpt
Loss of the tumor suppressor protein menin is a critical event underlying the formation of neuroendocrine tumors (NET) in hormone-expressing tissues including gastrinomas. While aberrant expression of menin impairs its tumor suppression, few studies explore the structure-function relationship of clinical multiple endocrine neoplasia, type 1 (MEN1) mutations in the absence of a complete LOH at both loci. Here, we...
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