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Antihypertensive effects of inducible nitric oxide synthase inhibition in experimental pre‐eclampsia

24 Jul 2013

Abstract excerpt

Upregulation of inducible nitric oxide synthase (iNOS) has been reported in both experimental and clinical hypertension. However, although pro-inflammatory cytokines that up-regulate iNOS contribute to pre-eclampsia, no previous study has tested the hypothesis that a selective iNOS inhibitor (1400 W) could exert antihypertensive effects associated with decreased iNOS expression and nitrosative stress in...

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PMID: 23890248
DOI: 10.1111/jcmm.12106

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