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Article

Identification of substrate orienting and phosphorylation sites within tryptophan hydroxylase using homology-based molecular modeling.

Journal of molecular biology - 29 Sept 2000

Jiang G C, Yohrling G J, Schmitt J D, Vrana K E, Yohrling G J, Schmitt I V

Abstract excerpt

Tryptophan hydroxylase (TPH) is the initial and rate-limiting enzyme in the biosynthesis of serotonin. The inherent instability of TPH has prevented a crystallographic structure from being resolved. For this reason, multiple sequence alignment-based molecular modeling was utilized to generate a full-length model of human TPH. Previously determined crystal coordinates of two highly homologous proteins,...

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Identifiers

PMID: 10993738
DOI: 10.1006/jmbi.2000.4097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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