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Article

Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation.

Cancer research - 15 Dec 2006

Yan Bin, Wang Huili, Rabbani Zahid N, Zhao Yulin, Li Wenrong, Yuan Yuqing, Li Fang, Dewhirst Mark W, Li Chuan-Yuan

Abstract excerpt

Tumor necrosis factor-alpha (TNF-alpha) is an important inflammation cytokine without known direct effect on DNA. In this study, we found that TNF-alpha can cause DNA damages through reactive oxygen species. The mutagenic effect of TNF-alpha is comparable with that of ionizing radiation. TNF-alpha treatment in cultured cells resulted in increased gene mutations, gene amplification, micronuclei formation, and...

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Source

Identifiers

PMID: 17178846
DOI: 10.1158/0008-5472.CAN-06-2540

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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