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Article

Furazolidone induced oxidative DNA damage via up-regulating ROS that caused cell cycle arrest in human hepatoma G2 cells.

Toxicology letters - 25 Mar 2011

Jin Xi, Tang Shusheng, Chen Qian, Zou Jiajie, Zhang Ting, Liu Fengying, Zhang Shen, Sun Chundi, Xiao Xilong

Abstract excerpt

Furazolidone (FZD) is an antimicrobial agent that has been shown to have mutagenic, genotoxic and potentially carcinogenic properties when tested in a variety of systems in vitro and in vivo. In this study, we investigated FZD's DNA damaging effect in human hepatoma cells aiming at further defining the molecular mechanism of FZD's cytotoxicity. Addition of FZD resulted in cell growth suppression and cell cycle...

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Identifiers

PMID: 21195149
DOI: 10.1016/j.toxlet.2010.12.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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