Article
Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis.
Arthritis research & therapy - 25 Jul 2011
Biniecka Monika, Kennedy Aisling, Ng Chin T, Chang Ting C, Balogh Emese, Fox Edward, Veale Douglas J, Fearon Ursula, O'Sullivan Jacintha N
Abstract excerpt
INTRODUCTION: To examine the effects of tumour necrosis factor (TNF) blocking therapy on the levels of early mitochondrial genome alterations and oxidative stress. METHODS: Eighteen inflammatory arthritis patients underwent synovial tissue oxygen (tpO(2)) measurements and clinical assessment of disease activity (DAS28-CRP) at baseline (T0) and three months (T3) after starting biologic therapy. Synovial tissue...
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