Article
The splicing factor crooked neck associates with the RNA-binding protein HOW to control glial cell maturation in Drosophila.
Neuron - 21 Dec 2006
Edenfeld Gundula, Volohonsky Gloria, Krukkert Karin, Naffin Elke, Lammel Uwe, Grimm Alexandra, Engelen Daniel, Reuveny Adriana, Volk Talila, Klämbt Christian
Abstract excerpt
In both vertebrates and invertebrates, glial cells wrap axonal processes to ensure electrical conductance. Here we report that Crooked neck (Crn), the Drosophila homolog of the yeast Clf1p splicing factor, is directing peripheral glial cell maturation. We show that crooked neck is expressed and required in glial cells to control migration and axonal wrapping. Within the cytoplasm, Crn interacts with the...
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