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Article

The permissive role of glucocorticoids on interleukin-1 stimulation of angiotensinogen gene transcription is mediated by an interaction between inducible enhancers.

Molecular and cellular biology - 1 Aug 1990

Ron D, Brasier A R, Wright K A, Habener J F

Abstract excerpt

The acute-phase activation of the rat angiotensinogen (rAT) gene in liver cells is a transcriptional event mediated through an interleukin-1-inducible, NF kappa B-binding, cis-acting element (the acute-phase response element [APRE]). Using a cell culture model for the acute-phase response, we showed that the increase in angiotensionogen mRNA in H35 rat hepatoma cells requires costimulation with glucocorticoids...

Topics

Angiotensinogen
Animals
Base Sequence
Cell Line
Dexamethasone
Enhancer Elements, Genetic
Genes
Interleukin-1
Liver Neoplasms, Experimental
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

RNA, Messenger

Rats

Transcription, Genetic

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 2370871
DOI: 10.1128/mcb.10.8.4389-4395.1990
PMCID: PMC360996

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2370871-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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