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Article

The Human β Fibrinogen Promoter Contains a Hepatocyte Nuclear Factor 1-Dependent Interleukin-6-Responsive Element

1 Feb 1993

Abstract excerpt

Acute-phase reactants are liver proteins whose synthesis is positively or negatively regulated during inflammation. The main mediators of this phenomenon are glucocorticoids and interleukin-6 (IL-6), a pleiotropic cytokine that also controls hematopoiesis. Functional analysis of several acute-phase reactant promoter regions has identified two major DNA motifs used by IL-6-regulated genes. The first one...

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Identifiers

PMID: 8423785
DOI: 10.1128/mcb.13.2.1183-1193.1993

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