Article
Structure, hormonal regulation, and identification of the interleukin-6- and dexamethasone-responsive element of the rat haptoglobin gene.
Molecular and cellular biology - 1 Apr 1990
Marinković S, Baumann H
Abstract excerpt
Hepatic expression of the haptoglobin (Hp) gene in mammalian species is stimulated severalfold during an acute-phase reaction. To identify the molecular mechanism responsible for this regulation, the single-copy rat Hp gene has been isolated. The genomic sequences showed a high degree of homology...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- Chromosome Deletion
- Dexamethasone
- Gene Expression Regulation
- Genes
- Genetic Vectors
- Haptoglobins
- Humans
- Interleukin-6
- Liver
- Liver Neoplasms, Experimental
- Male
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic