Article
Glucocorticoid receptor binding site in the mouse alpha-amylase 2 gene mediates response to the hormone.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 1993
Slater E P, Hesse H, Müller J M, Beato M
Abstract excerpt
Amylase gene expression has been shown to be positively regulated by glucocorticoids. Previous reports have suggested that this effect is indirect. We have addressed this question in a mouse exocrine pancreas cell line, 266-6, in which basal level of expression of amylase mRNA is low but inducible by glucocorticoids. In these cells the effect of glucocorticoids is not inhibited by cycloheximide at early time...
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