Article
Glucocorticoid receptor binding site in the mouse alpha-amylase 2 gene mediates response to the hormone.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 1993
Slater E P, Hesse H, Müller J M, Beato M
Abstract excerpt
Amylase gene expression has been shown to be positively regulated by glucocorticoids. Previous reports have suggested that this effect is indirect. We have addressed this question in a mouse exocrine pancreas cell line, 266-6, in which basal level of expression of amylase mRNA is low but inducibl...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- Cycloheximide
- DNA
- Dexamethasone
- Drug Resistance
- Gene Expression Regulation, Enzymologic
- Glucocorticoids
- Immunoblotting
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Pancreas
- Promoter Regions, Genetic
- RNA, Messenger