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Article

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance

28 Nov 2018

Abstract excerpt

It is currently believed that type I and III interferons (IFNs) have redundant functions. However, the preferential distribution of type III IFN receptor on epithelial cells suggests functional differences at epithelial surfaces. Here, using human intestinal epithelial cells we could show that although both type I and type III IFNs confer an antiviral state to the cells, they do so with distinct kinetics. Type I...

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PMID: 30485383
DOI: 10.1371/journal.ppat.1007420

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