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Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout

14 Aug 2003

Abstract excerpt

Patients with multiple endocrine neoplasia type 1 (MEN1) develop multiple endocrine tumors, primarily affecting the parathyroid, pituitary, and endocrine pancreas, due to the inactivation of the MEN1 gene. A conditional mouse model was developed to evaluate the loss of the mouse homolog, Men1, in the pancreatic beta cell. Men1 in these mice contains exons 3 to 8 flanked by loxP sites, such that, when the mice are...

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PMID: 12917331
DOI: 10.1128/mcb.23.17.6075-6085.2003

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