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Article

Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence.

Cell cycle (Georgetown, Tex.) - 1 Dec 2006

Feng Lijin, Hollstein Monica, Xu Yang

Abstract excerpt

Posttranslational modification such as phosphorylation of p53 plays important roles in activating p53 responses to various cellular and genotoxic stresses. Cell line studies have shown that phosphorylation of Ser46 is correlated with the activation of p53 apoptotic activity. To address the physiological roles of Ser46 phosphorylation, we employed homologous recombination and LoxP/Cre-mediated deletion to...

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PMID: 17172844
DOI: 10.4161/cc.5.23.3526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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