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Article

Identification of p53-46F as a super p53 with an enhanced ability to induce p53-dependent apoptosis.

Cancer science - 1 Jul 2006

Nakamura Yasuyuki, Futamura Manabu, Kamino Hiroki, Yoshida Koji, Nakamura Yusuke, Arakawa Hirofumi

Abstract excerpt

More than half of human cancers contain mutations in the tumor suppressor protein p53, most of which accumulate in the DNA binding domain of the protein. Here we report the identification of a mutant p53, designated p53-46F, in which Ser-46 is replaced with phenylalanine. In vitro, adenovirus-mediated transduction of the p53-46F gene induced apoptosis more efficiently than wild-type p53 in a number of cancer cell...

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Identifiers

PMID: 16827804
DOI: 10.1111/j.1349-7006.2006.00214.x
PMCID: PMC11158242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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