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Article

Rae1 interaction with NuMA is required for bipolar spindle formation.

Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2006

Wong Richard W, Blobel Günter, Coutavas Elias

Abstract excerpt

In eukaryotic cells, the faithful segregation of daughter chromosomes during cell division depends on formation of a microtubule (MT)-based bipolar spindle apparatus. The Nuclear Mitotic Apparatus protein (NuMA) is recruited from interphase nuclei to spindle MTs during mitosis. The carboxy terminal domain of NuMA binds MTs, allowing a NuMA dimer to function as a "divalent" crosslinker that bundles MTs. The...

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Identifiers

PMID: 17172455
DOI: 10.1073/pnas.0609582104
PMCID: PMC1750899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rae1 interaction with NuMA is required for bipolar spindle formation.PMID 17172455Read ↗

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