Article
Low glucocorticoid receptor alpha/beta ratio in T-cell lymphoblastic leukemia.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Oct 2000
Longui C A, Vottero A, Adamson P C, Cole D E, Kino T, Monte O, Chrousos G P
Abstract excerpt
Glucocorticoid therapy is pivotal in the treatment of acute lymphoblastic leukemia (ALL); it reduces cell proliferation, promotes cell cycle arrest, and induces cell death by apoptosis. The sensitivity of leukemic cells to glucocorticoids was previously related to the cell concentration of 3[H]dexamethasone-binding sites. The latter represents the classic glucocorticoid receptor (GR) isoform alpha that binds...
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