Article
Folate levels in mucosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis.
World journal of gastroenterology - 21 Dec 2006
Weng Yu-Rong, Sun Dan-Feng, Fang Jing-Yuan, Gu Wei-Qi, Zhu Hong-Yin
Abstract excerpt
AIM: To evaluate whether folate levels in mucosal tissue and some common methylenetetrahydrofolate reductase (MTHFR) variants are associated with the risk of gastric cancer through DNA methylation. METHODS: Real-time PCR was used to study the expression of tumor related genes in 76 mucosal tissue samples from 38 patients with gastric cancer. Samples from the gastroscopic biopsy tissues of 34 patients with chronic...
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