Article
Multiple evolutionarily conserved enhancers control expression of Eya1.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Nov 2008
Ishihara Tadashi, Sato Shigeru, Ikeda Keiko, Yajima Hiroshi, Kawakami Kiyoshi
Abstract excerpt
Eya1 is a homolog of eyes absent in Drosophila, and essential for various organ formations in vertebrates. Mouse and chick Eya1 shows dynamic expression pattern in early development. We identified ten independent Eya1 enhancers by screening evolutionarily conserved sequences. They exhibited enhancer activities in Hensen's node, neural tube, migrating neural crest cells, otic vesicle, olfactory placode, cranial...
Topics
- Animals
- Brain
- Chick Embryo
- Enhancer Elements, Genetic
- Evolution, Molecular
- Gene Expression Regulation, Developmental
- Humans
- Intracellular Signaling Peptides and Proteins
- Mice
- Mutation
- Nuclear Proteins
- Organ Specificity
- Protein Tyrosine Phosphatases
- Quantitative Trait Loci
- Somites
- Species Specificity