Article
New 3' elements control Pax6 expression in the developing pretectum, neural retina and olfactory region.
Mechanisms of development - 1 Mar 2002
Griffin Caroline, Kleinjan Dirk A, Doe Brendan, van Heyningen Veronica
Abstract excerpt
Pax6 is a key transcriptional regulator in eye, olfactory system, forebrain, pituitary cerebellum, spinal cord and pancreas development. Alternative splicing, promoter usage and multiple enhancers regulate the complex Pax6 spatio-temporal expression pattern. Chromosomal rearrangements which abolish PAX6 gene expression have been characterised downstream of the coding region. Through evolutionary sequence...
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