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Article

The ROP18 and ROP5 gene allele types are highly predictive of virulence in mice across globally distributed strains of Toxoplasma gondii.

International journal for parasitology - 1 Feb 2016

Shwab Elliot Keats, Jiang Tiantian, Pena Hilda F J, Gennari Solange M, Dubey Jitender P, Su Chunlei

Abstract excerpt

The protozoan parasite Toxoplasma gondii is one of the most successful known eukaryotic pathogens on Earth. Virulence of T. gondii strains varies greatly in mice, and mounting evidence suggests that such variations may be relevant to the manifestation of human toxoplasmosis. Polymorphic rhoptry-secreted kinases and pseudokinases (ROP) have been demonstrated to account for murine virulence among the archetypal...

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PMID: 26699401
DOI: 10.1016/j.ijpara.2015.10.005

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