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Article

Polymorphic secreted kinases are key virulence factors in toxoplasmosis.

Science (New York, N.Y.) - 15 Dec 2006

Saeij J P J, Boyle J P, Coller S, Taylor S, Sibley L D, Brooke-Powell E T, Ajioka J W, Boothroyd J C

Abstract excerpt

The majority of known Toxoplasma gondii isolates from Europe and North America belong to three clonal lines that differ dramatically in their virulence, depending on the host. To identify the responsible genes, we mapped virulence in F(1) progeny derived from crosses between type II and type III strains, which we introduced into mice. Five virulence (VIR) loci were thus identified, and for two of these, genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17170306
DOI: 10.1126/science.1133690
PMCID: PMC2646183

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