Article
Selection at a single locus leads to widespread expansion of Toxoplasma gondii lineages that are virulent in mice.
PLoS genetics - 1 Mar 2009
Khan Asis, Taylor Sonya, Ajioka James W, Rosenthal Benjamin M, Sibley L David
Abstract excerpt
Pathogenicity differences among laboratory isolates of the dominant clonal North American and European lineages of Toxoplasma gondii are largely controlled by polymorphisms and expression differences in rhoptry secretory proteins (ROPs). However, the extent to which such differences control virulence in natural isolates of T. gondii, including those from more diverse genetic backgrounds, is uncertain. We...
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