Article
Ortho-quinones of benzene and estrogens induce hyperproliferation of human peripheral blood mononuclear cells.
Leukemia & lymphoma - 1 Dec 2006
Chakravarti Dhrubajyoti, Zahid Muhammad, Backora Matthew, Myers Erin M, Gaikwad Nilesh, Weisenburger Dennis D, Cavalieri Ercole L, Rogan Eleanor G, Joshi Shantaram S
Abstract excerpt
Benzene is a known leukemogen. It has been hypothesized that benzene and natural estrogens initiate cancer by forming ortho-quinones (catechol quinones) that react with DNA in cells. These quinones form depurinating DNA adducts that generate the mutations leading to cancer. This study examined whether the treatment of normal human peripheral blood mononuclear cells with the ortho-quinones of benzene or estradiol...
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