Article
Exposure of hematopoietic stem cells to benzene or 1,4-benzoquinone induces gender-specific gene expression.
Stem cells (Dayton, Ohio) - 1 Jan 2004
Faiola Brenda, Fuller Elizabeth S, Wong Victoria A, Pluta Linda, Abernethy Diane J, Rose Jason, Recio Leslie
Abstract excerpt
Chronic exposure to benzene results in progressive decline of hematopoietic function and may lead to the onset of various disorders, including aplastic anemia, myelodysplastic syndrome, and leukemia. Damage to macromolecules resulting from benzene metabolites and misrepair of DNA lesions may lead to changes in hematopoietic stem cells (HSCs) that give rise to leukemic clones. We have shown previously that male...
Topics
- Animals
- Apoptosis
- Benzene
- Benzoquinones
- Carcinogens
- Cell Cycle Proteins
- Cell Transformation, Neoplastic
- Cells, Cultured
- DNA Damage
- DNA Repair
- Dose-Response Relationship, Drug
- Female
- Gene Expression Regulation, Neoplastic