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Article

Novel biomarkers for risk of prostate cancer: Results from a case–control study

24 Sept 2008

Abstract excerpt

BACKGROUND: Although the estrogens estrone and estradiol are recognized to play very important roles in the risk of developing prostate cancer (Pca), the molecular mechanism by which estrogens initiate and/or promote Pca is still unknown. Substantial evidence supports that specific metabolites of estrogens, catechol estrogen quinones, can react with DNA to form depurinating estrogen-DNA adducts. Apurinic sites...

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Share to Estrogen and related hormone effects
Share to Glutathione Transferases and Polymorphisms
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PMID: 18816637
DOI: 10.1002/pros.20850

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