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Article

A unifying mechanism in the initiation of cancer and other diseases by catechol quinones.

Annals of the New York Academy of Sciences - 1 Dec 2004

Cavalieri Ercole L, Rogan Eleanor G

Abstract excerpt

The first step in cancer initiation is the reaction of chemical carcinogens with DNA to form stable adducts, which remain in DNA unless removed by repair, and depurinating adducts, which detach from DNA following destabilization of the glycosyl bond. Depurinating DNA adducts of polycyclic aromatic hydrocarbons play a major role in the initiation of cancer, as shown by the correlation between depurinating adducts...

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Identifiers

PMID: 15650250
DOI: 10.1196/annals.1322.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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