Article
Molecular characterization of the human delta-aminolevulinate dehydratase 2 (ALAD2) allele: implications for molecular screening of individuals for genetic susceptibility to lead poisoning.
American journal of human genetics - 1 Oct 1991
Wetmur J G, Kaya A H, Plewinska M, Desnick R J
Abstract excerpt
The second enzyme in the heme biosynthetic pathway, delta-aminolevulinate dehydratase (ALAD), is a homooctameric protein encoded by a gene localized to human chromosome 9q34. Expression of the two common alleles, ALAD1 (p = .9) and ALAD2 (q = .1), results in a polymorphic enzyme system with three distinct charge isozymes, designated 1-1, 1-2, and 2-2. Individuals heterozygous (2pq = .18) or homozygous (q2 = .01)...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Chromosomes, Human, Pair 9
- Deoxyribonuclease HpaII
- Deoxyribonucleases, Type II Site-Specific
- Erythrocytes
- Genetic Testing
- Humans
- Isoenzymes