Article
A polymorphism in the delta-aminolevulinic acid dehydratase gene may modify the pharmacokinetics and toxicity of lead.
Environmental health perspectives - 1 Mar 1995
Smith C M, Wang X, Hu H, Kelsey K T
Abstract excerpt
Associations between the presence of a constitutional variant of delta-aminolevulinic acid dehydratase (ALAD-2) and lead concentrations in blood and bone, as well as between this allele and indices of kidney function, were investigated among 691 members of a construction trade union. The average...
Topics
- Adult
- Alleles
- Base Sequence
- Blood Urea Nitrogen
- Bone and Bones
- Construction Materials
- Heterozygote
- Homozygote
- Humans
- Lead
- Male
- Middle Aged
- Molecular Sequence Data
- Occupational Exposure
- Polymerase Chain Reaction
- Porphobilinogen Synthase