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Article

p53‐dependent neuronal cell death in a DJ‐1‐deficient zebrafish model of Parkinson's disease

1 Nov 2006

Abstract excerpt

Mutations in DJ-1 lead to early onset Parkinson's disease (PD). The aim of this study was to elucidate further the underlying mechanisms leading to neuronal cell death in DJ-1 deficiency in vivo and determine whether the observed cell loss could be prevented pharmacologically. Inactivation of DJ-1 in zebrafish, Danio rerio, resulted in loss of dopaminergic neurons after exposure to hydrogen peroxide and the...

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PMID: 17166173
DOI: 10.1111/j.1471-4159.2006.04291.x

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