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Article

Paraquat-Induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells: Involvement of p53 and Mitochondria

2 Feb 2008

Abstract excerpt

The herbicide paraquat is a suspected etiologic factor in the development of Parkinson's disease (PD). Paraquat was therefore used to reproduce Parkinsonian syndromes in lab animals, in which it produces dopaminergic pathogenesis. However, the factors or mechanisms by which paraquat kills dopaminergic neurons are not fully understood. Based on reported evidence that paraquat increases p53 protein levels and...

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PMID: 18253895
DOI: 10.1080/15287390701738467

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