Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulatory variation and evolution: implications for disease.

Advances in genetics - 1 Jan 2008

Dermitzakis Emmanouil T

Abstract excerpt

In the past few years, it has become apparent that there is a substantial amount of noncoding DNA that contributes to genome function. However, the multidimensionality of noncoding DNA properties does not allow us to readily identify, characterize, and assess the functional impact of mutations, polymorphisms, and interspecific substitutions. In this chapter, we discuss the evolutionary properties of some of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Evolution, Molecular
Share to Genetic Diseases, Inborn
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Biological

Share to Regulatory Sequences, Nucleic Acid

Share to RNA, Untranslated

Share to Selection, Genetic

Source

Identifiers

PMID: 18282511
DOI: 10.1016/S0065-2660(07)00011-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulatory variation and evolution: implications for disease.PMID 18282511Read ↗

Interpreting noncoding genetic variation in complex traits and human disease.Semantic proximity Read ↗

Finding Needles in the Haystack: Strategies for Uncovering Noncoding Regulatory Variants.Semantic proximity Read ↗

Evolutionary conservation in noncoding genomic regions.Semantic proximity Read ↗

Prospects for identifying functional variation across the genome.Semantic proximity Read ↗

The Role of Noncoding Variants in Heritable Disease.Semantic proximity Read ↗

Variation in vertebrate cis-regulatory elements in evolution and disease.Semantic proximity Read ↗

The genetic signatures of noncoding RNAs.Semantic proximity Read ↗

Searching for functional genetic variants in non-coding DNA.Semantic proximity Read ↗

Pathogenicity and selective constraint in the non-coding genomeSemantic proximity Read ↗

Genetic variation within transcriptional regulatory elements and its implications for human disease.Semantic proximity Read ↗

A survey of genomic properties for the detection of regulatory polymorphisms.Semantic proximity Read ↗

Long Noncoding RNAs in Mammalian Development and Diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.