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Article

Creation of a pair of stereochemically complementary biocatalysts.

Journal of the American Chemical Society - 20 Dec 2006

Williams Gavin J, Woodhall Thomas, Farnsworth Lorna M, Nelson Adam, Berry Alan

Abstract excerpt

N-Acetylneuraminic acid lyase (NAL) exhibits poor facial selectivity during carbon-carbon formation, and as such, its utility as a catalyst for use in synthetic chemistry is limited. For example, the NAL-catalyzed condensation between pyruvate and (2R,3S)-2,3-dihydroxy-4-oxo-N,N-dipropylbutyramide yields ca. 3:1 mixtures of diastereomeric products under either kinetic or thermodynamic control. Engineering the...

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PMID: 17165777
DOI: 10.1021/ja065233q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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