Article
T cell defined HLA epitopes and T cell receptor polymorphism in insulin dependent diabetes mellitus.
Bailliere's clinical endocrinology and metabolism - 1 Jun 1991
Sheehy M J
Abstract excerpt
T cell defined epitopes on class II HLA molecules (epitopes distinguishable by T cells but not by antibodies) seem to be important determinants of IDDM susceptibility/resistance. Although HLA-DR4 is associated with IDDM in many populations, DR4-positive HLA haplotypes vary greatly (relative risk...
Topics
- Alleles
- Diabetes Mellitus, Type 1
- Epitopes
- Genetic Predisposition to Disease
- HLA Antigens
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DR3 Antigen
- HLA-DR4 Antigen
- HLA-DRB1 Chains
- Haplotypes
- Histocompatibility Antigens Class II
- Humans
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Receptors, Antigen, T-Cell
- T-Lymphocytes