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Article

Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis.

BMC gastroenterology - 12 Dec 2006

Bhaskar Seema, Reddy D N, Mahurkar Swapna, Rao G V, Singh Lalji, Chandak Giriraj R

Abstract excerpt

BACKGROUND: The genetic basis of tropical calcific pancreatitis (TCP) is different and is explained by mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene. However, mutated SPINK1 does not account for the disease in all the patients, neither does it explain the phenotypic heterogeneity between TCP and fibro-calculous pancreatic diabetes (FCPD). Recent studies suggest a crucial role for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Peptidyl-Dipeptidase A

Share to Trypsin Inhibitor, Kazal Pancreatic

Source

Open in PubMed Open full text

Identifiers

PMID: 17163998
DOI: 10.1186/1471-230X-6-42
PMCID: PMC1762011

Genes

ACE
SPINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis.PMID 17163998Read ↗

Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants.Semantic proximity Read ↗

Genetic and phenotypic heterogeneity in tropical calcific pancreatitis.Semantic proximity Read ↗

Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis.Semantic proximity Read ↗

Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants.Semantic proximity Read ↗

Idiopathic chronic pancreatitis in India: phenotypic characterisation and strong genetic susceptibility due to SPINK1 and CFTR gene mutations.Semantic proximity Read ↗

The functional angiotensin converting enzyme gene I/D polymorphism does not alter susceptibility to chronic pancreatitis.Semantic proximity Read ↗

Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis.Semantic proximity Read ↗

TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes.Semantic proximity Read ↗

Angiotensin-converting enzyme insertion/deletion polymorphism in patients with acute and chronic pancreatitis.Semantic proximity Read ↗

Mutations in the pancreatic secretory trypsin inhibitor gene (<i>PSTI</i>/<i>SPINK1</i>) rather than the cationic trypsinogen gene (<i>PRSS1</i>) are significantly associated with tropical calcific pancreatitisSemantic proximity Read ↗

Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis.Semantic proximity Read ↗

Association between angiotensin-converting enzyme gene insertion/deletion polymorphism and pancreatitis risk: A meta-analysis.Semantic proximity Read ↗

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