Article
Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis.
Gut - 1 Sept 2006
Mahurkar S, Idris M M, Reddy D N, Bhaskar S, Rao G V, Thomas V, Singh L, Chandak G R
Abstract excerpt
BACKGROUND AND AIMS: Tropical calcific pancreatitis (TCP) is a type of chronic pancreatitis unique to countries in the tropics. Mutations in pancreatic secretory trypsin inhibitor (SPINK1) rather than cationic trypsinogen (PRSS1) explain the disease in only 50% of TCP patients. As cathepsin B (CTSB) is known to activate cationic trypsinogen, we attempted to understand the role of CTSB mutations in TCP. Evidence...
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