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Article

Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants.

Gut - 1 Nov 2013

Paliwal Sumit, Bhaskar Seema, Mani K Radha, Reddy D Nageshwar, Rao G Venkat, Singh Shivaram Prasad, Thomas Varghese, Chandak Giriraj Ratan

Abstract excerpt

OBJECTIVE: In a previous study, the authors have shown that rather than variants in trypsinogen gene(s), mutations in pancreatic secretory trypsin inhibitor (encoded by SPINK1) and cathepsin B (CTSB) are associated with tropical calcific pancreatitis (TCP). Recently, chymotrypsin C (CTRC) variants that diminish its activity or secretion were found to predict susceptibility to chronic pancreatitis (CP). The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Trypsin Inhibitor, Kazal Pancreatic

Source

Identifiers

PMID: 22580415
DOI: 10.1136/gutjnl-2012-302448

Genes

CTRC
CTSB
SPINK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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