Mutations in the pancreatic secretory trypsin inhibitor gene (<i>PSTI</i>/<i>SPINK1</i>) rather than the cationic trypsinogen gene (<i>PRSS1</i>) are significantly associated with tropical calcific pancreatitis

Abstract excerpt

Pancreatitis is a global health care problem with varied aetiologies. Alcoholism is responsible in the majority of patients while other causes, such as heredity, gallstones, hyperlipidaemia, hypercalcaemia, and idiopathic pancreatitis, are relatively rare.1,2 The causal factor in 20-30% of such cases is still not known and they fall into the category of idiopathic chronic pancreatitis (ICP).1,2 Although the exact...

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