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Article

Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jan 2009

Sundaresan Santhosh, Chacko Ashok, Dutta Amit K, Bhatia Eesh, Witt Heiko, Te Morsche René H M, Jansen Jan B M J, Drenth Joost P H

Abstract excerpt

BACKGROUND/AIMS: Tropical calcific pancreatitis (TCP) refers to a type of idiopathic pancreatitis prevalent in Asia. The trypsin inhibitor (SPINK1) N34S variant partially explains the genetic susceptibility to TCP. As anionic trypsinogen (PRSS2) G191R protects against chronic pancreatitis in Europeans, we investigated whether this variant protects from TCP in Indians. METHODS: We enrolled 174 patients and 794...

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Share to Amino Acid Substitution
Share to Calcinosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Pancreatitis, Chronic

Share to Trypsin

Share to Trypsin Inhibitor, Kazal Pancreatic

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Source

Identifiers

PMID: 19077465
DOI: 10.1159/000178885

Genes

SPINK1
PRSS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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