Article
TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes.
BMC medical genetics - 16 Aug 2008
Mahurkar Swapna, Bhaskar Seema, Reddy D Nageshwar, Prakash Swami, Rao G Venkat, Singh Shivaram Prasad, Thomas Varghese, Chandak Giriraj Ratan
Abstract excerpt
BACKGROUND: Tropical calcific pancreatitis (TCP) is a type of chronic pancreatitis unique to developing countries in tropical regions and one of its important features is invariable progression to diabetes, a condition called fibro-calculous pancreatic diabetes (FCPD), but the nature of diabetes in TCP is controversial. We analysed the recently reported type 2 diabetes (T2D) associated polymorphisms in the TCF7L2...
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