Article
Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38(MAPK)/MK2 axis.
Scientific reports - 5 Aug 2016
Ronkina Natalia, Lafera Juri, Kotlyarov Alexey, Gaestel Matthias
Abstract excerpt
Myocardin-related transcription factor A (MRTF-A) is a known actin-regulated transcriptional coactivator of serum response factor (SRF). Stimulation of actin polymerization activates MRTF-A by releasing it from G-actin and thus allowing it to bind to and activate SRF. Here, we compared protein phosphorylation in MK2/3-deficient cells rescued or not by ectopic expression of MK2 in two independent phosphoproteomic...
Topics
- Animals
- Anisomycin
- Fibroblasts
- HEK293 Cells
- HeLa Cells
- Humans
- Intracellular Signaling Peptides and Proteins
- Lipopolysaccharides
- Macrophages
- Mice
- Mutation
- Phosphorylation
- Protein Serine-Threonine Kinases
- Proteomics
- Serine
- Signal Transduction
- Stress, Physiological
- Trans-Activators